Differential potentiation by nystatin of the effect of antibiotics on yeast and mammalian cells.
نویسنده
چکیده
The effect of the polyene antibiotic nystatin, used in combination with several other antibiotics, on the membranes of Candida albicans SC#8169 (yeast) cells and of Chinese hamster ovary and 3T3 (mammalian) cells was investigated. It was concluded from determinations of the viability of the yeast cells and from measurements of deoxyribonucleic acid synthesis by the mammalian cells that nystatin acts synergistically with several antibiotics on yeast cells, but not on CHO and 3T3 cells. This selective action of nystatin may prove useful in chemotherapy.
منابع مشابه
Potentiation of antiviral activity of acyclovir by polyene macrolide antibiotics.
The potentiation of the antiviral activity of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] by polyene macrolide antibiotics has been studied as a function of the macrolide structure. The 12 polyenes chosen for this study represented the major structural groups of these antibiotics and induced in mammalian cells repairable membrane alterations or irreversible cell damage. The potentiating acti...
متن کاملEvaluation of Anti biofilm and Antibiotic Potentiation Activities of Silver Nanoparticles Against some Nosocomial Pathogens
Nowadays silver nanoparticles (AgNPs) are used as antimicrobial due to its well known physical, chemical, and biological properties. A large collection of bacterial cells adhering to a surface is called bacterial biofilm. Exposure to silver nano particles (AgNPs) may prevent colonization of new bacteria onto the biofilm. In the present work, we have investigated whether the biofilm format...
متن کاملEffect of fatty acids on action of polyene antibiotics.
Fatty acids cause a decrease in the absorption spectra of the antifungal polyene macrolide antibiotics nystatin, filipin, candicidin, and amphotericin B. For nystatin, filipin, and candicidin, this decrease in absorption could be correlated with the activity of the fatty acids in protecting the yeast Saccharomyces cerevisiae against the action of these antibiotics. With amphotericin B a correla...
متن کاملPotentiation Effect Of 5FU by Fragaceatoxin C Pore-Forming Toxin in MCF-7 Cell Line
Introduction: Chemotherapy has been restricted due to the high-dose side effects. In the present study, acceleration of the chemotherapeutic drug (5FU) entrance into MCF-7 cells has been explored by using a recombinant form of Fragaceatoxin C (FraC) pore-forming toxin. Methods: In this experimental study, the gene for FraC toxin was order from a commercial source and was sub-cloned into pET28a...
متن کاملEffect of nystatin on the utilization of substrates by yeast and other fungi.
Nystatin2 is one of a group of polyene antifungal antibiotics discovered in recent years (Hazen and Brown, 1951; Oroshnick et al., 1955). It contains a conjugated tetraene grouping and a diene unit, a carbonyl and a primary amino group, and has a molecular weight of approximately 950 (Dutcher et al., 1955). Nystatin inhibits the growth of most fungi at concentrations between 1 and 10 jig per ml...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 7 6 شماره
صفحات -
تاریخ انتشار 1975